Topic: RiboTag mice

Midbrain dopaminergic (mDA) neurons play important roles in controlling a variety of brain functions. An abnormal development of the dopaminergic circuits can lead to different brain disorders. In addition, degeneration of mDA neurons is the leading cause of Parkinson’s disease. Dopamine neurons in the midbrain form a heterogeneous set of neurons that innervate different regions of the brain. However, the developmental mechanisms regulating the precise organization of these neuronal circuits remain poorly understood. Recent discoveries have revealed that a proportion of the proteins used for t