The interplay between mTORC2 and oxidative stress in neurotoxic models of neurodegeneration
Marija Jeremic, Andjelka Isakovic, Vladimir Trajkovic, Ivanka Markovic · FENS Forum 2024
1-Methyl-4-phenyl-pyridinium (MPP+) and 6-hydroxydopamine (6-OHDA) are the predominant neurotoxic agents used in the research of Parkinson's disease (PD). The mTORC2 is a significant signaling pathway whose specific functions and mechanisms remain partially elusive, especially in the context of PD-related oxidative stress. We aimed to determine the interconnection between mTORC2 and oxidative stress in MPP+ and 6-OHDA neurotoxic models of PD. All experiments were performed on the human neuroblastoma cell line, SH-SY5Y. Cells were divided into two groups: control (consists of control cells and
ePoster · Neuroscience