RNA-binding properties influence phase separation of TDP-43 in vivo
Cindy Maurel, Natalie Scherer, Grant Richter, Rowan Radford, Alison Hogan, Tyler Chapman, Albert Lee, Roger Chung, Marco Morsch · FENS Forum 2024
TDP-43 is the hallmark protein of several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). This RNA-binding protein can form membrane-less condensates through liquid-liquid phase separation (LLPS). This biophysical process is considered to contribute to the regulation of TDP-43 functions but the precise mechanisms governing TDP-43 LLPS and its implications in homeostasis as well as pathology remain incompletely understood.In this study, we aimed to elucidate the influence of RNA-binding on TDP-43 dynamics and localization in vivo. By applying confocal imaging workflow
ePoster · Neuroscience