Topic: RNA/DNA binding protein

Amyotrophic lateral sclerosis (ALS) is characterized by the nuclear depletion and cytoplasmic aggregation of an essential RNA/DNA binding protein, TDP-43. TDP-43 is a key constituent of neuronal ribonucleoprotein (RNP) granules involved in post-transcriptional mRNA regulation, including splicing, mRNA localization and translation of transcripts important for synaptic and axonal maintenance. We and others have previously shown that ALS-linked TDP-43 mutations in the LCD impair axonal transport of RNP granules. Specifically, we found that mutations in the conserved helical segment and flanking r