Microglia morphophysiological diversity and its implications for the CNS after peripheral nerve injury
Andres Vidal-Itriago, Rowan A Radford, Pradeep Manuneedhi Cholan, Cindy Maurel, Albert Lee, Roger S Chung, Manuel B Graeber, Marco Morsch · FENS Forum 2024
Microglia are phagocytes responsible for the homeostasis and immune responses in the central nervous system (CNS). Peripheral nerve injury (axotomy) models have greatly contributed to our understanding of microglial response to neurodegeneration. Here we established the first avulsion axotomy model in zebrafish. Using in vivo confocal imaging we have characterized the long-term dynamics of microglia-neuron interactions in response to peripheral nerve injury.In vivo time-lapse imaging confirmed that peripheral nerve injury triggered a microglial response in the CNS. This response was characteri
ePoster · Neuroscience