Ia inputs are uncoupled from activity-dependent intracellular signaling in motoneurons from SOD1 mice
Kamil Grycz, Piotr Zawistowski, Burak Özkan, Francesco Roselli, Daniel Zytnicki, Marcin Bączyk · FENS Forum 2024
Ia glutamatergic synapses on spinal motoneurons (MNs) are functionally and structurally impaired in the SOD1 mouse model of ALS at a presymptomatic stage. However, we do not know the consequence of such a synaptic impairment on intracellular activity-dependent signaling. To investigate this issue we focused on activity-dependent signaling pathways: CaMKIV/CREB and ERK/S6. Unilateral small vibrations at high frequencies were applied to the Achilles tendon in order to activate the spindle primary endings in triceps surae (TS), eliciting Ia inputs to homonymous motoneurons. In vivo intracellular
ePoster · Neuroscience