The circadian molecular clock in mPFC modulates the depressive phenotype and represents a potential treatment pathway
David Sarrazin, Wilf Gardner, Martin Balzinger, Tsvetan Serchov · FENS Forum 2024
Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased oscillation of clock negative regulatory loop, as well as a phase shift of Bmal1 expression in the medial prefrontal cortex (mPFC) of a mouse model of depression (depression-like behavior and anhedonia induced by daily 10 min swim sessions for 5 consecutive days). Selective disruption of mPFC clockwork with viral Bmal1KO in CaMK2a excitatory neurons blocks the development of depressive-like phenotype in our model of depre
ePoster · Neuroscience