Exploring the role of axonal voltage-gated sodium channels in the modulation of dopamine release by presynaptic nicotinic receptors
Lucille Duquenoy, Mahnoor Khurram, Bethan M. O'Connor, Yukun A. Hao, Sungmoo Lee, Michael Z. Lin, Katherine R. Brimblecombe, Stephanie J. Cragg · FENS Forum 2024
Striatal dopamine (DA) and acetylcholine (ACh) play key roles in reward prediction signalling and goal-directed behaviour. Midbrain DA neurons increase their firing in response to unexpected rewards or reward-predicting cues, while striatal cholinergic interneurons exhibit coincident burst-pause activity. Striatal DA and ACh also reciprocally regulate each other’s release with ACh modulating DA release through axonal nicotinic acetylcholine receptors (nAChRs). Activation of nAChRs can drive DA release but also generate strong short-term depression (STD) of subsequent DA release, not arising fr
ePoster · Neuroscience