Regulation of anxiety-related behaviors by leptin receptor-expressing neurons in the lateral hypothalamus
Rebecca Figge-Schlensok, Anne Petzold, Nele Hugger, Tatiana Korotkova · FENS Forum 2024
A reduction of food intake – and concurrent loss of body weight – in combination with physical hyperactivity are main symptoms of the eating disorder anorexia nervosa. Continuous loss of fat mass results in hypoleptinemia, which initiates multiple starvation-related adaptive functions. Although leptin administration showed beneficial effects in treatment of symptoms of anorexia nervosa, including anxiety, neuronal mechanisms of possible anxiety-relieving action of leptin are not known.Here, combining calcium imaging and opto- or chemogenetics in freely behaving mice, we investigated functions
ePoster · Neuroscience