Effect of acute and chronic activation of relaxin-3 receptor (RXFP3) on contextual fear acquisition and extinction in the rat retrosplenial cortex
Mónica Navarro Sánchez, Isis Gil-Miravet, Daniel Montero-Caballero, Mohamed Aly Ebraheem Zahran, Aroa Mañas-Ojeda, Esther Castillo-Gómez, Francisco. E Olucha-Bordonau · FENS Forum 2024
The retrosplenial cortex (RSC) is known for its pivotal role in contextual fear conditioning, receiving inputs from both corticocortical and subcortical pathways, including the nucleus incertus in the pontine tegmentum. This region contains a GABAergic projection rich in relaxin-3 (RLN3), which acts via its Gi/o-protein-coupled receptor, RXFP3. To investigate the involvement of this peptidergic system in contextual fear conditioning, we bilaterally injected adult rat RSC with an adeno-associated virus (AAV) expressing the chimeric RXFP3 agonist R3/I5 or a control AAV and subjected them to cont
ePoster · Neuroscience