Brief application of (S)-ketamine causes long-term depression of NMDA receptor-mediated synaptic transmission in the mouse hippocampus
Muchun Han, Patrick Tidball, John Georgiou, Graham L. Collingridge · FENS Forum 2024
Ketamine, an open-channel blocker of the N-methyl-D-aspartate receptor (NMDAR), has been shown to have rapid and sustained antidepressant effects after a single sub-anesthetic dose. Among its two enantiomers, (S)-ketamine acts more potently at NMDARs than (R)-ketamine, and its use as an antidepressant was approved by the FDA in 2019. Given that the mechanism underlying ketamine’s sustained antidepressant action remains unclear, we investigated if (S)-ketamine has any long-term effect on NMDAR-mediated synaptic transmission. In extracellular recordings from the CA1 region of mouse hippocampal s
ePoster · Neuroscience