Re-emergence of T lymphocytes-mediated synaptopathy in progressive multiple sclerosis
Federica Palmerio, Krizia Sanna, Antonio Bruno, Sara Balletta, Silvia Caioli, Monica Nencini, Diego Fresegna, Livia Guadalupi, Ettore Dolcetti, Federica Azzolini, Fabio Buttari, Roberta Fantozzi, Angela Borrelli, Mario Stampanoni Bassi, Luana Gilio, Valentina Vanni, Francesca De Vito, Alessandra Musella, Diego Centonze, Georgia Mandolesi · FENS Forum 2024
Secondary progressive multiple sclerosis (SPMS) is an autoimmune neurodegenerative disease characterized not only by white matter compromission, but also by synaptopathy in the grey matter. This lead to an unbalanced Glutamatergic/GABAergic transmission mediated by T lymphocytes infiltration. Here, we explore the possible synaptoprotective effects of Siponimod, a sphingosine 1-phosphate receptor (S1PR) modulator, demonstrated to reduce the accumulation of disability and grey matter damage in SPMS patients.Chimeric experiments were performed by incubating human T cells on murine (C57BL/6) corti
ePoster · Neuroscience