Sonogenetics: From the mechano-sensitive channel to brain stimulation for visual restoration
Erwan Dessailly, Ignacio Alcala, Matthieu Provencal, Audrey Leong, Rafik Arab, Pierre Pouget, Fabrice Arcizet, Serge Picaud · FENS Forum 2024
In the pursuit of restoring vision for patients having lost the eye-brain connection, ultrasound stimulation is a new interesting therapeutic approach at the cortical level. In particular, Sonogenetic therapy has been explored as a mean to increase the sensitivity of cells to ultrasound by expressing a mechanosensitive ion channel in the membranes of cells of interest in order to modulate their activity.In order to optimize sonogenetics for vision restoration, we first focused on exploring the properties of different mechano-sensitive ion channels, the key parameters being the spatial and temp
ePoster · Neuroscience