Topic: safe option

Maladaptive decision-making under risk is a feature of various neuropsychiatric disorders, yet the underlying neural circuits remain largely unexplored. The orbitofrontal cortex (OFC) is a main region for action-reward updating and flexible behaviors, is likely to play in this process. Our study aimed to investigate the role of the OFC in decision-making under risk. We developed a task requiring rats to choose between a safe option leading to a modest gain and a risky option which may earn a larger, but not guaranteed reward. Different probabilities were associated with the risky option so tha