Salt-induced kinase 3 is activated upon mGlu2 receptor stimulation and exerts a negative feedback on the receptor canonical signaling
Candice Disdier, Clémentine Philibert, Yéléna Martin, Sonya Galant, Olga Göransson, Philippe Marin, Franck Vandermoere · FENS Forum 2024
Metabotropic glutamate receptor 2 (mGlu2) is a G protein-coupled receptor expressed in the central nervous system and canonically coupled to Gi/o protein. mGlu2 receptor is the main target of a new generation of antipsychotics which showed unprecedent efficiency on negative and cognitive symptoms of Schizophrenia, which were so far resisting to actual antipsychotics. However, the molecular mechanisms regulating the antipsychotic properties of mGlu2 receptor stimulation remain unclear. In a recent interactomic screen (Philibert et al., Science Advances, 2024), we demonstrated that endogenous mG
ePoster · Neuroscience