Discovery of dual inhibitors for the treatment of Alzheimer's disease
Aina Bellver Sanchis, Ainoha Sanchez-Arfelis, Alba Irisarri, Santiago Vázquez, Carmen Escolano, Christian Griñán-Ferré · FENS Forum 2024
Alzheimer’s disease (AD) is the most common cause of dementia. Until now, none of the approved AD treatments turned out to be a success. AD is unknown but involves genetic, biochemical, and environmental factors. Thus, one of the reasons why single-target-directed drugs have failed to reach clinical trials is the pathological complexity found in AD. It could be better contrasted by the development of Multiple Targeting Directed Ligands (MTDLs), which can modulate simultaneously multiple targets involved in the onset of the pathology. As a new strategy in drug discovery for AD, compared to comb
ePoster · Neuroscience