Topic: Sapap3 mutant mice

Dysregulation in the cortico-striatal circuits has been shown to be related to pathologic repetitive behaviors but the underlying dysfunctional mechanisms at the microcircuit level remain under investigation. A key element that regulate the striatal output iare striatal parvalbumin (PV) interneurons which exert a powerful feedforward inhibition on medium spiny neurons. To investigate the role of PV interneurons in regulating aberrant striatal activity observed in repetitive behaviors, we used the Sapap3 mutant mice, which exhibit excessive self-grooming. Using optogenetics activation of PV int