Topic: SATB2-associated syndrome

SATB2, encoding a DNA-binding nuclear protein, is genetically associated with human intelligence and schizophrenia. Individuals with SATB2 haploinsufficiency suffer from SATB2-associated syndrome defined by developmental delay, severe intellectual disability, and absent/limited speech. In a previous study we have identified epigenetic profiles and higher-order chromatin interactions that depend on SATB2 in cortical pyramidal neurons of the mouse by integrating high-resolution, multidimensional datasets from Satb2 conditional knockout (cKO) and floxed mice. With remarkable specificity, SATB2-me