Saporin-anti-vesicular GABA transporter conjugates as lesioning agents in the rat basolateral amygdala – A potential tool to create a new animal model of pathological anxiety?
Tamara Radukic, Milica Zeljkovic Jovanovic, Danica Popovic, Ivana Stevanovic, Milorad Dragic, Marina Zaric Kontic · FENS Forum 2024
The basolateral amygdala (BLA) regulates emotional behavior and reactions and its hyperexcitability is closely related to anxiety and fear. Given that selective degeneration of local GABAergic interneurons could lead to increased anxiety-like behavior, our aim was to test the efficacy of commercially available saporin-anti-vesicular GABA transporter conjugates (SAVA) and their ability to alter the parameters of anxiety-like behavior. For this purpose, adult male Wistar rats were divided into three experimental groups treated with different SAVA doses (20, 40 and 80 ng per injection site, 6 ani
ePoster · Neuroscience