Topic: SB-612111

Migraine is a neurological disorder manifested by throbbing pain, allodynia, as well as light sensitivity (photophobia). Despite continuing research, the pathogenesis of the disease is not precisely understood. Structures implicated in migraine formation, including the trigeminal ganglia and trigeminal nucleus caudalis, exhibit a particularly high expression of Nociceptin Opioid (NOP) receptors. The aim of the study was to compare the effect of selective and non-selective NOP receptor agonists on acute migraine symptoms induced by systemic administration of nitroglicerin (NTG). NTG induces mig

Migraine, a neurological disorder characterized by recurring, intense headaches, disproportionately affects a significant portion of the population, particularly females. While its precise etiology remains elusive, it is thought to have arisen from a combination of genetic predisposition and environmental factors. This research endeavors to explore the neurobiological underpinnings of both the sensory and emotional aspects of migraine pain, as well as the associated social impairments. Using the nitroglycerin (NTG) migraine model, which induces vasodilation via systemic administration, we simu