Changes in endocannabinoid-dependent synaptic plasticity in CA1 hippocampus of a mouse model of temporal lobe epilepsy
Amaia Mimenza, Itziar Bonilla-Del Río, Izaskun Elezgarai, Nagore Puente, Pedro Grandes · FENS Forum 2024
Temporal lobe epilepsy (TLE) is one of the most prevalent neurological disorders, affecting 1-3% people worldwide. As this type of epilepsy is often refractory to anticonvulsant drugs, it is crucial to advance the understanding of the mechanisms that underlie its pathophysiology. The endocannabinoid system (ECS) protects nerve cells through the cannabinoid CB1 receptor regulation of the glutamatergic neuronal excitability. As TLE patients frequently show changes in the ECS, in this study we analyze the impact of the status epilepticus in the hippocampus four weeks after administraton of the pr
ePoster · Neuroscience