Heterozygosity for neurodevelopmental disorder-associated TRIO variants leads to distinct deficits in neuronal development and function
Yevheniia Ishchenko, Amanda T. Jeng, Shufang Feng, Timothy Nottoli, Melissa G. Carrizales, Matthew J. Vitarelli, Ellen Corcoran, Cindy Manriquez-Rodriguez, Khanh Nguyen, Charles A. Greer, Samuel A. Myers, Anthony J. Koleske · FENS Forum 2024
TRIO is a high-risk gene for schizophrenia (SCZ) and autism spectrum disorder (ASD) also variants found in patients with bipolar disorder (BPD). TRIO regulates small-GTPases to control neuronal migration, synapse development and function. However, it remains unclear whether and how discrete TRIO variants differentially impact these neurodevelopmental events. Here, we use murine models to investigate heterozygous variants that impact TRIO catalytic activity and are linked to NDDs: (TRIO) +/K1431M (ASD), +/K1918X (SCZ), and +/M2145T (bipolar disorder, BPD). Heterozygosity for Trio variants impac
ePoster · Neuroscience