Movement initiation reveals a hyperactive direct pathway in a mouse model of dystonia
Filipa França de Barros, Marcelo Mendonça, Diogo Soares Melo, Susanne Knorr, Lisa Rauschenberger, Chi Wang Ip, Rui M Costa, Albino Oliveira-Maia, Joaquim Alves da Silva · FENS Forum 2024
Dystonia is a movement disorder characterized by involuntary muscle contractions that are often worsened by movement initiation. Theoretical models propose that dystonic movements emerge due to an imbalance of the direct (D1-Medium spiny neurons, MSNs) and indirect (D2-MSNs) basal ganglia pathways. However, dystonia’s pathophysiology remains largely unknown. Thus, we explored the activity of genetically identified MSNs during self-paced movement in a mouse model of inherited dystonia.Adult DYT-TOR1AΔGAG knock-in (DYT) mice and wild-type (WT) expressing Cre recombinase under the control of the
ePoster · Neuroscience