Boosting as therapeutic approach a homeostatic response played by cholecystokinin (CCK)-positive basket GABAergic neurons in Scn1a+/- Dravet syndrome mice
Evgeniia Rusina, Paolo Scalmani, Fabrizio Capitano, Fabrice Duprat, Massimo Mantegazza · FENS Forum 2024
We have identified a homeostatic response in a Scn1a+/- mouse model of Dravet syndrome (DS), a developmental and epileptic encephalopathy caused by genetic variants of the SCN1A gene, leading to loss of function of the NaV1.1 sodium channel and consequent hypoexcitability of GABAergic neurons. Strikingly, we observed that cholecystokinin (CCK)-positive basket cells are hyperexcitable, unlike other GABAergic neurons, leading to increased release of CCK, which is a neuromodulator that can increase the excitability of other GABAergic interneurons. We have boosted this homeostatic response in a th
ePoster · Neuroscience