Time is of the essence: Exploring excitation/inhibition imbalance driving distinct functional network phenotypes in ASD
Nicky Scheefhals, Nikki Kolsters, Eline van Hugte, Sofía Puvogel, Marie Le Bihan, Chantal Schoenmaker, Ka Man Wu, Dirk Schubert, Nael Nadif Kasri · FENS Forum 2024
Neurodevelopment is a finely orchestrated process marked by the sequential, but intimately connected events of synapse formation, maturation, and the critical GABA shift, where GABAergic neurotransmission transitions from excitatory to inhibitory. The precise timing and intricate balance of excitatory and inhibitory signaling is crucial for establishing functional neural circuits, and when disrupted contribute to neurodevelopmental disorders (NDDs) like autism spectrum disorder (ASD) and epilepsy. Exploring human aspects of neuronal development and functioning face challenges due to limitation
ePoster · Neuroscience