Brain-wide circuitry underlying altered auditory habituation in zebrafish models of autism
Maya Wilde, Anahita Ghanbari, Tessa Mancienne, Ailís Moran, Rebecca Poulsen, Lena Constantin, Conrad Lee, Leandro Aluisio Scholz, Joshua Arnold, Timothy Karle, Itia Favre-Bulle, Ellen Hoffman, Ethan Scott · FENS Forum 2024
Auditory processing is widely understood to occur differently in autism, though the exact brain activity underlying these differences is not well understood. The diversity of autism also means there may be multiple ways the network can change to produce a similar behavioural output. We used larval zebrafish to investigate auditory habituation in four genetic models of autism: fmr1, mecp2, scn1lab and cntnap2. Larval zebrafish are optically transparent, enabling whole-brain imaging of neural activity at single-cell resolution using genetically encoded calcium indicator GCaMP6s. In free-swimming
ePoster · Neuroscience