Gain-of-function (GOF) variants of the Nav1.2 sodium channel have been strongly associated with a spectrum of developmental disorders, among which epilepsy is a commonly observed feature. Although prior studies conducted in heterologous expression systems have successfully delineated the biophysical mechanism underlying the GOF mutations, the comprehensive understanding of how a GOF mutation influences cellular and synaptic properties during the critical periods of development, and subsequently how these alterations impact cellular maturation, remains somewhat elusive.We studied the CA3 pyrami
ePoster · Neuroscience