Diurnal variation of learning and memory and molecular approach in mice and nonhuman primates
Kimiko Shimizu, Yodai Kobayashi, Ken-ichi Inoue, Masahiko Takada, Takao Oishi, Hiroo Imai, Yoshitaka Fukada · FENS Forum 2024
Cognitive functions like learning and memory depend on the time of day in various organisms. We have demonstrated that long-term recognition memory performance revealed an apparent diurnal/circadian change with the peak during the early night in nocturnal mice. SCOP (PHLPP1b) is a key molecule regulating hippocampus-dependent long-term memory in mice. The amounts of SCOP in the hippocampus exhibit robust circadian changes. Long-term memory formation in recognition memory is regulated by the circadian clock through SCOP dynamics in the hippocampal CA1 in nocturnal mice. Whether diurnal changes
ePoster · Neuroscience