The Tabulae Paralytica: Multimodal single-cell atlas of spinal cord injury
Alan Yue Yang Teo, Michael A. Skinnider, Matthieu Gautier, Claudia Kathe, Thomas H. Hutson, Achilleas Laskaratos, Alexandra de Coucy, Nicola Regazzi, Viviana Aureli, Nicholas D. James, Bernard Schneider, Michael V. Sofroniew, Quentin Barraud, Jocelyne Bloch, Mark A. Anderson, Jordan W. Squair, Gregoire Courtine · FENS Forum 2024
Spinal cord injury (SCI) is a complex disorder that triggers a cascade of biochemical processes interwoven by cell-type specific responses after the initial injury. This progressive cascade is collectively termed the "secondary injury", and involves inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar with an astrocyte border. Here, we turn to single-cell technology to unravel the underlying cellular and molecular tapestry of SCI. We compiled a series of comprehensive single-cell atlases of the injured mou
ePoster · Neuroscience