Distinct calcium sources regulate the temporal profiles of NMDAR and mGluR mediated protein synthesis in neurons
Bindushree Kapu Radhakrishna, Sarayu Ramakrishna, Nisa Shah, Ahamed Kaladiyil, Nimisha Basavaraj, Kristine Freude, Reddy Kommaddi, Ravi Muddashetty · FENS Forum 2024
Calcium, an important secondary messenger, lies at the hub of multiple signaling pathways. The increase in cytosolic calcium contributed by different calcium-permeable channels can create transient high-calcium microenvironments and activate distinct signaling cascades in neurons. The spatio-temporal calcium changes, and calcium-mediated signaling pathways act as critical regulators of synaptic plasticity. Here, we have studied the regulation of activity-mediated protein synthesis by calcium response generated on NMDAR or mGluR stimulation in rat primary cortical neurons. Using calcium imaging
ePoster · Neuroscience