Unravelling the mechanisms behind development of quiescent neural stem cells: The role of Presenilin 1
Surya Suresh, Jyothi Pradeep Nair, Meera Vadakkath, Riya Paul Ann, Parvathy Surendran, Rahul Jose, Swathy Vankudoth, Avyanga Sankaranarayanan, Jackson James · FENS Forum 2024
During embryonic development, some of the proliferating neural stem cells enter a quiescent state and is retained till adulthood, thus contributing to adult neurogenesis, a process involving different proteins. From a published microarray of Presenilin-1 knock out embryo, one such protein, VCAM1 was found to be significantly downregulated. In addition, Presenilin-1(PS1) is known to be involved in embryonic neurogenesis as well as in cell cycle regulation. Based on these, we hypothesized PS1 to have a role in neural stem cell quiescence.To address this, we modelled quiescence in vitro by additi
ePoster · Neuroscience