Topic: Secreted Frizzled-related protein 1

Alzheimer’s disease (AD), like other neurodegenerative disorders (NDs), is associated with chronic inflammation of the central nervous system via astrocyte and microglia activation. Previous work from our lab described Secreted Frizzled-related protein 1 (SFRP1) as a novel player in AD pathogenesis and neuro-inflammatory chronicity by modulating astrocyte-microglia crosstalk. The gut microbiome has increasingly attracted attention for its possible contribution to NDs through the gut-brain axis. In fact, microbiota-derived metabolites, such as short chain fatty acids (SCFA), have been related t