Topic: secretomics

Parkinson’s disease (PD) is a neurodegenerative disorder that is mainly characterised by the loss of dopaminergic neurons in the substantia nigra as well as the presence of aggregates called Lewy bodies which consist mostly of alpha-synuclein. Astrocytes and microglia are increasingly being regarded as key players in PD-associated neurodegeneration, and these become ‘activated’ during neuroinflammation. Autophagy and its dysfunction have been implicated in some genetic forms of PD, with alpha-synuclein accumulation and aggregation linked to autophagy suppression. Using alpha-synuclein triplica