Topic: secretory pathway

Midbrain dopamine (DA) neurons possess complex branching structures and demand significant metabolic resources . This intricate architecture makes these neuron susceptible, emphasizing the role of intracellular trafficking in the early development of Parkinson's disease (PD). Recent genetic screenings in Asian and European populations have unveiled SV2C (synaptic vesicle glycoprotein C) as a newly discovered gene associated with PD. Specifically, the D543N mutation has been linked to PD. It is hypothesized that this mutation introduces a new glycosylation site in the SV2C protein, underscoring