Astroglial connexins differentially drive chronic seizures in mice and humans
Razmig Derounian, Giselle Cheung, Elena Dossi, Julien Moulard, Glenn Dallérac, Agnès Villers, Pascal Ezan, Gilles Huberfeld, Laurent Capelle, Johan Pallud, Thomas Blauwblomme, Chun-Yao Lee, Nathalie Rouach · FENS Forum 2024
Astrocytic dysfunctions have increasingly been recognized as a significant element in epilepsy pathophysiology. The prominent expression of connexin channels is one of the key features of astrocytes, essential for their extensive intercellular coupling. It is currently debated whether astrocytic connexins have pro- or anti-epileptic effects. The existence of two types of connexins, namely Cx30 and Cx43, which display different properties as well as several functions beyond gap junction formation, such as hemichannel constituents or signaling elements, further makes it more complex to investig
ePoster · Neuroscience