Antiepileptic medication is associated with excitatory synaptic strengthening in pyramidal neurons of the adult human neocortex
Amelie Eichler, Maximilian Lenz, Pia Kruse, Han Lu, Sandra Diaz, Jakob Strähle, Paul Turko, Hanna Hemeling, Phyllis Stöhr, Imre Vida, Jürgen Beck, Andreas Vlachos · FENS Forum 2024
The concept of homeostasis is a central principle in many biological systems, and aims at maintaining systems in a functional state. In the brain homeostatic synaptic plasticity is a well-known mechanism to maintain neuronal networks in a functional homeostasis. Despite there has been a lot of research and characterization of this form of plasticity in animal models, it remains unknown, whether it is also expressed in the human brain. In this study, we investigated the impact of treatment with antiepileptic drugs on neurotransmission and functional properties of layer 2/3 pyramidal cells in th
ePoster · Neuroscience