Topic: semaphorin-1a

We hypothesize that the principle of wiring economy provides a compelling constraint for the spatial arrangement of Drosophila olfactory glomeruli. By comparing the wiring cost of actual glomerular organization with random configurations, we validated the role of wiring economy in shaping the spatial distribution of glomeruli. Building on this, we modeled three potential spatial organization strategies---the ‘onion’ model, the ‘orange’ model, and the ‘floor’ model---to compare the assembly strategy under the lens of wiring economy. Our calculations revealed that both the ‘floor’ and ‘orange’ m