Topic: senescence-accelerated mice

The circadian rhythm and sleep architecture of senescence-accelerated mice (SAM)P8 and SAMR1 were evaluated to utilize SAM as a model of age-related sleep disorders. The evaluation of the circadian rhythm based on the locomotor activity was performed from 1 to 5 months old SAMP8 and SAMR1. At 6 months of age, mice were chronically implanted with electroencephalograph and electromyogram electrodes for polysomnographic recording of sleep-wake states. The vigilance states were automatically classified by SleepSign ver.3 software. First, the circadian rhythm was evaluated. Comparing the locomotor