ePoster · Neuroimmunology
Presence and characterization of neo-epitopes in mouse brain
Clara Romera Niño, Raquel Alsina, Marta Riba, Jordi Vilaplana, Carme Pelegrí, Jaume del Valle · FENS Forum 2024
Brain ageing in mice leads to the progressive appearance of degenerative granular structures frequently referred to as “PAS granules” because of their positive staining with periodic acid-Schiff (PAS). It has been reported that these granules contain neo-epitopes that can be recognised by natural IgM auto-antibodies, and proposed that they intervene in a brain cleaning mechanism. Some preliminary studies seem to indicate that these neo-epitopes are also present in other structures than PAS granules, so the aim of this work has been to study and characterize the presence of neo-epitopes in mice