OPCs modulate neuronal activity via direct contact on the lysosome releasing site of neurons
Lipao Fang, Ching-Hsin Lin, Yasser Medlej, Hsin-Fang Chang, Davide Gobbo, Qilin Guo, Wenhui Huang, Anja Scheller, Frank Kirchhoff, Xianshu Bai · FENS Forum 2024
Oligodendrocyte precursors (OPCs) possess numerous processes and neurons are abundantly distributed in the brain. We wondered whether OPCs form other types of contact with neurons, apart from synapses. Immunohistochemical analysis exhibited that OPC processes contact somata of inhibitory and excitatory neurons equally well, with preference for active neurons. In addition, more contacts were observed when neurons were chemogenetically stimulated. Utilizing stimulated emission depletion (STED) microscopy, lysosomes were identified in the neuronal compartment at the contact site, particularly the
ePoster · Neuroscience