All-optical mapping of feedback and sensory-evoked synaptic inputs to pyramidal neurons in the mouse primary somatosensory cortex
Céline Dürst, David van Oorschot, Elodie Husi, Anthony Holtmaat · FENS Forum 2024
The rodent's primary somatosensory cortex (S1) processes sensory information from the whiskers on the snout. During active sensation, cortical pyramidal neurons integrate feedforward and a variety of feedback inputs to form a percept. In S1, feedback input from the higher-order (HO) posteromedial thalamic complex (POm) was shown to facilitate NMDAR-mediated nonlinear dendritic events in L2/3 neurons, which enhance synaptic plasticity and promote spiking. Such events greatly depend on the spatial and temporal arrangement of synaptic activity. However, the spatiotemporal relationship between HO
ePoster · Neuroscience