The NKCC1 inhibitor bumetanide restores cortical feedforward inhibition and lessens sensory hypersensitivity in early postnatal Fragile X mice
Nazim Kourdougli, Toshihiro Nomura, Michelle Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Cailliau · FENS Forum 2024
Exaggerated responses to sensory stimuli is a hallmark of Fragile X syndrome (FXS), contributes to, inattention, anxiety, and learning challenges. Such sensory hypersensitivity are recapitulated in the Fmr1 knockout (KO). Recent studies in Fmr1 KO mice have demonstrated differences in GABAergic inhibition, including activity of cortical interneurons as well as a delayed switch in the polarity of GABA signaling during development. Previously, we found that administration of bumetanide to block the chloride (Cl-) transporter NKCC1, could rescue synaptic circuit phenotypes in primary somatosensor
ePoster · Neuroscience