ePoster · Neuroscience
Large-scale circuit dissection of schizophrenia using a rare variant mouse model
Jeff Stedehouder, Yangfan Peng, Katerina Panti, Charlotte J Stagg, Andrew Sharott · FENS Forum 2024
Schizophrenia is a major debilitating psychiatric disorder with a lifetime prevalence of ~1%, and its clinical presentation encompasses positive, negative, and cognitive symptoms. Despite decades of research, the underlying neurophysiology has remained elusive.Here, we examine the large-scale neurophysiology underlying schizophrenia by employing multiple, simultaneous Neuropixel recordings in rodents carrying a rare genetic variant implicated in the disease. Three or four Neuropixel probes were simultaneously targeted to prefrontal cortices, motor cortices, striatum, hippocampus, auditory cort