Adenosine triggers astrocyte reactivity to drive the pathogenesis of sepsis-associated encephalopathy
Qilin Guo, Davide Gobbo, Na Zhao, Qing Liu, Li-Pao Fang, Tanja M. Gampfer, Markus R. Meyer, Xianshu Bai, Anja Scheller, Frank Kirchhoff, Wenhui Huang · FENS Forum 2024
Molecular signals mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. In this study, we demonstrate that peripheral lipopolysaccharide (LPS)-induced systemic inflammation could rapidly increase the plasma adenosine concentration, peaking at 6 hours post LPS injection (hpi). Using in vivo 2P-LSM imaging of adenosine sensor GRABAdo, we observed elevated adenosine levels in the cortex of awake mice, also peaking at 6 hpi. These concomitant pathological events strongly suggest adenosine in the circulation can join forces to
ePoster · Neuroscience