Specific ablation of hippocampal theta activity during locomotion impairs learning
Abhilasha Joshi, Alison E. Comrie, Abhijith Mankili, Jennifer A. Guidera, Samuel Bray, Rhino Nevers, Xulu Sun, Emily Monroe, Viktor Kharazia, Daniela Astudillo Maya, Denisse Morales-Rodriguez, Jai Yu, Anna Kiseleva, Victor Perez, Loren M Frank · FENS Forum 2024
The ability to rapidly learn about new environments and new spatial relationships is critical for survival. The hippocampus plays a crucial role in that learning, and specialized features of hippocampal population coding including network-level theta oscillatory activity, location-specific firing of principal cells, and reactivation of experience during immobility have been implicated in the rapid storage and retrieval of new spatial information. Disruptions of theta and reactivation jointly, or reactivation itself, are sufficient to impair learning, but the specific contribution of locomotion
ePoster · Neuroscience