Presynaptic calcium dynamics in cytosol and ER and the interplay of ER membrane located pumps and channels
Nicole Flores-Pretell, Ranjita Dutta Roy, Markus Breit, Markus M. Knodel, Gabriel Wittum · FENS Forum 2024
Understanding the mechanisms regulating Ca2+ concentrations in the presynapse is crucial for addressing synaptic function. Most factors contributing to short-term plasticity, serving as a historical record of past synaptic transmission, are located in the presynaptic terminal. We investigated the influence of calcium exchange in different spatial compartments and the dynamics of calcium concentration in the cytosol and the endoplasmic reticulum (ER). Thus, we unveiled the impact of calcium in the ER on the dynamics of cytosolic calcium concentration in response to action potentials. We establi
ePoster · Neuroscience