Dissecting the Functional Organization of the Serotonergic System at Whole-Brain Scale in C. elegans
Di Kang, Ugur Dag, Ijeoma Nwabudike, Matthew Gomes, Eric Bueno, Jungsoo Kim, Adam Atanas, Cassi Estrem, Sarah Pugliese, Ziyu Wang, Emma Towlson, Steven Flavell · COSYNE 2023
Serotonin signaling is evolutionarily ancient and controls many aspects of behavior. The principles by which serotonin acts on its diverse types of receptors to modulate neural circuit activity and resultant behavior is poorly understood. Here, we examine how serotonin released from a food-responsive neuron in C. elegans alters neural activity at whole-brain scale to induce adaptive behaviors, such slow locomotion and increased pharyngeal pumping. A comprehensive in vivo genetic analysis of the six C. elegans serotonin receptors identifies three core serotonin receptors that sense serotonin re
Sat, Mar 11, 2023