Neurodevelopmental roles of the serotonin 5-HT6 receptor in a corticogenesis model from mouse embryonic stem cells
Clémence Quittet, Sonya Galant, Tristan Bouchet, Serge Urbach, Philippe Marin, Séverine Chaumont-Dubel · FENS Forum 2024
The serotonin 5-HT6 receptor (5-HT6R) is a G protein-coupled receptor only expressed in the central nervous system. It is a promising target for treating cognitive deficits observed in neurodevelopmental diseases, such as autism spectrum disorders (ASD). Our team has demonstrated a crucial role for the 5-HT6R in neurodevelopment. It participates in neuronal migration, the initiation of neurite growth and dendritic arborization, through interactions with different protein partners. We also confirmed that this receptor is mainly expressed in the primary cilium of neurons and astrocytes, except f
ePoster · Neuroscience