Fronto-striatal dynamics and optogenetic approaches to remodel impulsive choice
Nikita Gorbunov, Catharina Hamann, Philip Tovote, Tatyana Strekalova, Klaus-Peter Lesch · FENS Forum 2024
Tryptophan hydroxylase (TPH) is crucial for serotonin production, and TPH2 is primarily expressed in neurons. Human TPH2 variants are associated with major depressive, bipolar, and attention-deficit/hyperactivity disorders. Tph2 knockout (KO) in mice increases impulsivity and aggression. An imbalance in several transmitter systems, including serotoninergic signalling, also influences the process of medial prefrontal cortex (mPFC) development. The BALB/cJ mouse model with low serotonin shows altered distribution of Parvalbumin-positive (PV+) interneurons in the anterior cingulate (ACC) and midc
ePoster · Neuroscience