New circuit for respiratory depression, anesthesia, and slow wave oscillations: Mu-opioids→MHb→IPN→DRN + PAG + MRN
Karin Vadovicova · FENS Forum 2024
I show new idea how mu-opioids and high prenatal nicotine cause respiratory slowdown linked toslow wave sleep. A high dose of mu-opioids overstimulates the medial habenula whichactivates the interpeduncular nucleus. The IPN causes respiratory depression via its output toPAG, DRN, MRN, or LPO-RMTg.SWS is linked to a natural slowdown of respiration and heart rate. The MHb and rostromedial tegmental nucleus are known for high amount of mu-opioid receptors. Both MHb and RMTg were proposed to be activated in the neural circuit that promotes SWS, rest, immune defense and recovery (Vadovičová, 2015).
ePoster · Neuroscience